Santo Domingo is a barangay in the city of Santa Rosa, in the province of Laguna. Its population as determined by the 2020 Census was 6,863. This represented 1.65% of the total population of Santa Rosa.

The household papulation of Santo Domingo in the 2015 Census was 4,092 broken down into 1,260 households or an average of 3.25 members per household.

According to the 2015 Census, the age group with the highest population in Santo Domingo is 25 to 29, with 521 individuals. Conversely, the age group with the lowest population is 80 and over, with 19 individuals.

The population of Santo Domingo grew from 867 in 1990 to 6,863 in 2020, an increase of 5,996 people over the course of 30 years. The latest census figures in 2020 denote a growth rate of 11.50%, or an increase of 2,771 people, from the previous population of 4,092 in 2015.

Santo Domingo is situated at approximately 14.2284, 121.0479, in the island of Luzon. Elevation at these coordinates is estimated at 144.7 meters or 474.7 feet above mean sea level.

Santo Domingo shares a common border with the following barangay(s):
• Hukay, Silang, Cavite
• Puting Kahoy, Silang, Cavite
• Pittland, Cabuyao, Laguna
• Ganado, Biñan, Laguna
• Mampalasan, Biñan, Laguna
• Biñan (Poblacion), Biñan, Laguna
• Diezmo, Cabuyao, Laguna
• Don Jose, Santa Rosa, Laguna
• Casile, Cabuyao, Laguna